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Your diet is especially important when you have T2DM because what you eat will impact your blood sugar

Clinicians should consider GLP-1 therapy when lifestyle modificationsincluding dietary changes and increased physical activityhave proven insufficient to achieve weight loss goals

While the data doesnt provide any insights into how these benefits occurred, researchers did note that there was early reduction in heart disease events observed with semaglutide prior to what is typically considered significant weight loss. Some researchers suggest this means patients who are obese with established CVD should start semaglutide as soon as possible

Labs such as glucose/HbA1c, kidney function, and lipids may be ordered to guide safe GLP-1 prescribing

Nonetheless, the presumed loop (if it exists) would likely be important for the early postprandial phase at a time when the L-cells of the distal gut are not yet in direct contact with luminal nutrients